C&EN: Easy Route to Microcapsules

Chemical and Engineering News

February 13, 2012 (p37)

Researchers at the University of Cambridge have used supramolecular host-guest chemistry to fabricate cargo-carrying microcapsules from microfluidic droplets in a single step (Science, DOI: 10.1126/science.1215416). Oren A. Scherman, Chris Abell, and coworkers chose cucurbit[8]uril as the host molecule because it can form a ternary complex with two guests—in this case, methyl viologen attached to gold nanoparticles and a naphthol-containing copolymer. The researchers combined individual solutions of the three components in a microfluidic device to form a single aqueous phase. The oil phase shears droplets off the aqueous phase at a T junction. As the oil phase carries the droplets through a winding channel, the components combine to form hollow micro capsules consisting of a dispersion of gold nanoparticles in a polymer mesh held together by cucurbit[8]uril. The size of the microcapsules ranges from 10 to 24 μm and varies with the ratio of the oil and aqueous flow rates. The researchers can load a variety of cargo—such as drugs, biological molecules, and even cells—in the microcapsules by adding a fourth solution to the aqueous phase during fabrication.

 

Contact us

If you’d like to know more about our supramolecular solutions and how we can help your business and brand please get in touch.